BRD6989

BRD6989

Biochem/physiol Actions

BRD6989 is an inhibitor of cyclin-dependent kinase 8 (CDK8) that upregulates production of interleukin-10 (IL-10). BRD6989 was shown to bind cyclin C–CDK8 complex selectively with an IC50 value ~200 nM and to inhibit the kinase activity of recombinant cyclin C–CDK8 or cyclin C–CDK19 complexes with IC50 values ~500 nM and >30 µM, respectively. It enhanced the production interleukin-10 (IL-10) enhances IL-10 production in activated human and murine macrophages and dendritic cells with an EC50 value ~1 µM.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575962 BRD6989 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£402.54 (exc VAT) per 25MG
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3575963 BRD6989 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£124.24 (exc VAT) per 5MG
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