BQU57

BQU57

Biochem/physiol Actions

BQU57 is a selective inhibitor of the Ras-like GTPases RalA and RalB, downstream mediators of Ras signalling, without direct inihibition of Ras or RhoA activity . BQU57 binds to a site on the GDP-bound form of Ral, its inactive state, inhibiting the binding of Ral to its effectors, such as Ral-binding protein 1 (RALBP1; also known as RLIP760, which are involved in proliferation, survival, and metastasis of several human cancers. BQU57 inhibited growth in human luung cancer cell lines with IC50 values of 2.0 µM in H2122 cells and 1.3 µM in H358 cells, and also inihbited tumor xenograft growth.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574684 BQU57 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
£472.18 (exc VAT) per 25MG
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3574685 BQU57 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
£137.75 (exc VAT) per 5MG
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