BPV(PIC)

BPV(PIC)

Application

bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.

Biochem/physiol Actions

bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.

bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 µM for PTPβ and 61 µM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).

Other Notes

Light Sensitive

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574202 BPV(PIC) faintly yellow to dark yellow 100 SIGMA-ALDRICH −20°C
£360.75 (exc VAT) per 25MG
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3574203 BPV(PIC) faintly yellow to dark yellow 100 SIGMA-ALDRICH −20°C
£136.78 (exc VAT) per 5MG
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