BPV(HOPIC)

BPV(HOPIC)

Application

bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.

Biochem/physiol Actions

bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 µM for PTPβ and 25.3 µM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.

Other Notes

Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574200 BPV(HOPIC) faintly yellow to dark yellow 100 SIGMA-ALDRICH −20°C H2O: 20 mg/mL, clear powder ≥90% V basis
£409.50 (exc VAT) per 25MG
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3574201 BPV(HOPIC) faintly yellow to dark yellow 100 SIGMA-ALDRICH −20°C H2O: 20 mg/mL, clear powder ≥90% V basis
£150.43 (exc VAT) per 5MG
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