BPK-29

BPK-29

Biochem/physiol Actions

BPK-29 is a potent and selective NR0B1 ligand that covalently binds to NR0B1 Cys 274. BPK-29 inhibits the NR0B1-SNW1 interaction. It inhibits the anchorage-independent growth of KEAP1-mutant cancer cells.

BPK-29 is a small molecule inhibitor that blocks the nuclear factor erythroid 2–related factor 2 (NRF2) pathway. It targets the cysteine 274 residue in the nuclear receptor subfamily 0 group B member 1 (NR0B1) and disrupts protein-protein interactions in non-small-cell lung cancer (NSCLC) cell proteomes.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576122 BPK-29 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£427.61 (exc VAT) per 25MG
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3576123 BPK-29 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£139.29 (exc VAT) per 5MG
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