BIS-14-(4-METHOXYBENZENESULFONAMIDYL)

BIS-14-(4-METHOXYBENZENESULFONAMIDYL)

Biochem/physiol Actions

Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene is a non-covalent inhibitor of the interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2). The Keap1–Nrf2 protein–protein interaction is considered a critical point of the Keap1–Nrf2–ARE (antioxidant response elements) system that protects cells from oxidative stress. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene prevents Keap1 repression of Nrf2 activation, allowing Nrf2 to initiate antioxidant response element (ARE) to protect the cell. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene has an IC50 of 2.7 micromolar and specifically binds to the Keap1 Kelch-DC domain.

Features and Benefits

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Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574294 BIS-14-(4-METHOXYBENZENESULFONAMIDYL) , white to light yellow to light gray 100 SIGMA-ALDRICH 2-8°C
£412.29 (exc VAT) per 25MG
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3574295 BIS-14-(4-METHOXYBENZENESULFONAMIDYL) , white to light yellow to light gray 100 SIGMA-ALDRICH 2-8°C
£156.00 (exc VAT) per 5MG
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