BEPRISTAT 1A

BEPRISTAT 1A

Biochem/physiol Actions

Bepristat 1a is a selective reversible inhibitor of protein disulfide isomerase (PDI), an enzyme in the endoplasmic reticulum that catalyzes disulfide bond breakage and reformation to catalyze protein folding. Unlike most PDI inhibitors, Bepristat 1a binds at the substrate-binding site, rather than the catalytic site. It blocked PDI activity with an IC50 value of 700 nM. PDI is up-regulated in several cancers, has been implicated in neurodegenerative processes, and plays an important role in thrombus formation. Bepristat 1a potently inhibited platelet aggregation and thrombus formation in vivo.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575904 BEPRISTAT 1A white to light brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£551.57 (exc VAT) per 25MG
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3575905 BEPRISTAT 1A white to light brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£139.29 (exc VAT) per 5MG
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