BAY 60-2770

BAY 60-2770

Biochem/physiol Actions

BAY 60-2770 is a potent and selective soluble guanylyl cyclase (sGC) heme-independent activator that protects sGC from heme oxidation in smooth muscle tissues. BAY 60-2770 provides cardioprotection and limits the infarct size in rat ischaemia-reperfusion model. Also BAY 60-2770 Ameliorates of urethra dysfunction in high-fat fed obese mice.

Structurally, BAY 60-2770 comprises fluoro and trifluoromethyl moieties. It stimulates in vitro expressed ?2/?1 isoform of nitric oxide sensitive guanylyl cyclase (NOsGC). BAY 60-2770 is reported to be effective in treating liver fibrosis and in lowering arterial pressures (both pulmonary and systemic) in animal studies. It elicits anti-aggregating and anti-adhesive effects on platelets and may have therapeutic potential to treat atherothrombotic events.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576081 BAY 60-2770 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£702.00 (exc VAT) per 25MG
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3576082 BAY 60-2770 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£175.50 (exc VAT) per 5MG
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