AZM475271

AZM475271

Biochem/physiol Actions

AZM475271 (M475271) is an orally active, potent and selective inhibitor against src family kinases src and yes (IC50 = 25 nM & 10 nM, respectively; lck/VEGFR2/EGFR/csk/FGFR1 IC50 = 0.2/0.5/0.6/7.6/~20 µM) that effectively suppresses src-dependent cellular signaling events (26%/48% inhibition of 50 ng/mL VEGF-induced HUVEC proliferation/migration at 100 nM; 31%/72% inhibition of 10 ng/mL VEGF-induced Flk-1/Src phosphorylation in HUVECs at 300 nM) and exbihits anticancer efficacy both in cultures (70% PC-9/30% A549 proliferation inhibition at 1 µM) and in vivo (78%/100% PC-9 tumor growth suppression in mice via 10/50 mg/kg/day p.o.).

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576516 AZM475271 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£968.04 (exc VAT) per 25MG
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3576517 AZM475271 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£136.50 (exc VAT) per 5MG
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