AZD1480 HPLC

AZD1480 HPLC

Application

AZD1480 has been used as an inhibitor of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in an in vitro cell model of upper gastrointestinal adenocarcinoma. It has also been used in combination with bortezomib to study tumor-associated macrophage-mediated survival of myeloma cells.

Biochem/physiol Actions

AZD1480 is an orally active, potent and selective inhibitor of Janus kinases JAK1 and JAK 2 with selectivity for JAK2 as evidenced by IC50 values of 1.3 nM for JAK1 and ﹤0.4 nM for JAK2 in enzyme assays. AZD1480 inhibits endogenous as well as IL-6 induced STAT3 activation. AZD1480 reduces myeloid cell-mediated angiogenesis and metastasis. AZD1489 is an effective anticancer agent in bot adult and pediatric human tumors.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574998 AZD1480 HPLC white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£685.29 (exc VAT) per 25MG
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3574999 AZD1480 HPLC white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£169.93 (exc VAT) per 5MG
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