AZD-2098

AZD-2098

Biochem/physiol Actions

AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 µM) with little or no activity toward a panel of ~120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 µmol/kg p.o.; 1 h before and every 12 h after antigen challenge).

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576067 AZD-2098 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£474.96 (exc VAT) per 25MG
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3576068 AZD-2098 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£117.98 (exc VAT) per 5MG
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