ATN-161

ATN-161

Application

ATN-161 has been used as an inhibitor of integrin ?5?1 and ?v?3 in cultured platelet endothelial cell adhesion molecule (PECAM1)-positive endothelial cells isolated from AL (CECAL).

Biochem/physiol Actions

ATN-161 is a non-RGD based integrin binding peptide derived from the synergy region of fibronectin that inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 was shown to have antiangigenic and antitumor activity.

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Code Description Colour Manufacturer Storage Temp. Form Assay Price Quantity
3575791 ATN-161 white to beige SIGMA-ALDRICH −20°C powder ≥98% (HPLC)
£718.71 (exc VAT) per 25MG
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3575792 ATN-161 white to beige SIGMA-ALDRICH −20°C powder ≥98% (HPLC)
£178.29 (exc VAT) per 5MG
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