AR231453

AR231453

Biochem/physiol Actions

AR231453 is a 5-nitropyrimidine derivative that acts as a highly potent and selective GRP119 agonist (EC50/GPR119 species = 0.4 nM/monkey, 1.6 nM/dog, 4.7 nM/hamster, 3.5 nM/human, 12 nM/mouse, 4 nM/rat in cell-based assays), exhibiting no off-target activity toward 216 receptors, enzymes, and orphan GPCRs. AR231453 improves glucose tolerance in mice (3 mg/kg i.p. or 20 mg/kg, p.o.) and rats (3 mg/kg i.p.), while no in vivo efficacy is observed among GPR119-deficient mice.

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575503 AR231453 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£605.89 (exc VAT) per 25MG
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3575504 AR231453 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£121.32 (exc VAT) per 5MG
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