Apamin, from bee venom, >=95% (HPLC)

Apamin, from bee venom, >=95% (HPLC)

Amino Acid Sequence

Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 [Disulfide Bridges: 1-11, 3-15]

Application

Apamin has been used: As a selective inhibitor of small conductance (SKCa) channels in HEK cells.To inhibit endothelium-derived relaxing factor (EDHF) mediated responses.To block small-conductance Ca2-activated K current (ISK) in electrophysiological studies in hyperstriatum ventrale, pars caudalis (HVc) neurons.

Biochem/physiol Actions

Apamin is a neurotoxin and is cytotoxic to erythrocytes. Exposure to apamin leads to hypermotility and convulsions.

The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.

General description

Apamin is a bee venom component and is strongly basic in nature. It has 18 amino acid residues and two disulphide bonds.

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Code Description Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3589411 Apamin, from bee venom, >=95% (HPLC) 200 YVIIHEKJCKCXOB-STYWVVQQSA-N 1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110 SIGMA-ALDRICH powder ≥95% (HPLC)
£585.00 (exc VAT) per 1MG
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3589412 Apamin, from bee venom, >=95% (HPLC) 200 YVIIHEKJCKCXOB-STYWVVQQSA-N 1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110 SIGMA-ALDRICH powder ≥95% (HPLC)
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