ALX 5407 HYDROCHLORIDE

ALX 5407 HYDROCHLORIDE

Application

ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

Biochem/physiol Actions

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 µM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574216 ALX 5407 HYDROCHLORIDE white to beige 100 RPDGSZCYSJWQEE-GNAFDRTKSA-N 1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1 SIGMA-ALDRICH DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£481.93 (exc VAT) per 25MG
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3574217 ALX 5407 HYDROCHLORIDE white to beige 100 RPDGSZCYSJWQEE-GNAFDRTKSA-N 1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1 SIGMA-ALDRICH DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£153.21 (exc VAT) per 5MG
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