alpha-Melanocyte stimulating hormone, >=97% (HPLC)

alpha-Melanocyte stimulating hormone, >=97% (HPLC)

Amino Acid Sequence

Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Antibody Adsorbant

Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Application

?-Melanocyte stimulating hormone (?–MSH) has been used for following studies: it has been Intracerebroventricularly (icv) injected to mice for behavioral studies. to determine the effect of ??MSH on growth of stationary Nb 2 node lymphoma cell cultures. to determine the effect of ??MSH on leptin secretion in the primary cultures of differentiated adipocytes. ??MSH promoted melanin production in the B16-F1 cells from murine melanoma cell line.

Biochem/physiol Actions

Pituitary hormone which causes darkening skin pigmentation from amphibians to humans. In mammals, it can also have behavioral effects on learning, attention, and memory.

?-Melanocyte-stimulating hormone (?-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-? and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. ??MSH inhibits nuclear factor-?B (NF-?B)-dependent gene transcription and NF-?B pathway induced by TNF and other inflammatory agents. This activity of ?-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. ?–MSH functions as a potent therapeutics for various conditions resulted through NF-?B activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock. ?-MSH has an essential role to play in melanin production in animals. ?-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Hormone that stimulates melanogenesis; facilitates learning and memory; affects inflammatory and immune responses and peripheral nerve regeneration.

General description

?-Melanocyte-stimulating hormone (?-MSH) is a tridecapeptide, mostly produced by the cells in the brain, pituitary and circulation. Pro-inflammatory cytokines or UV light induced epidermal cells such as keratinocytes and melanocytes synthesize and discharge ?–MSH. Poopiomelanocortin (POMC) acts as a precursor for ?-Melanocyte-stimulating hormone (?-MSH) production.

Linkage

Derived from ACTH 1-13

Other Notes

Lyophilized from 0.1% TFA in H2O

Packaging

1, 5 mg in glass bottle

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Code Description Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3591768 alpha-Melanocyte stimulating hormone, >=97% (HPLC) 200 WHNFPRLDDSXQCL-UAZQEYIDSA-N 1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(1 SIGMA-ALDRICH powder ≥97% (HPLC)
£228.43 (exc VAT) per 1MG
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3591769 alpha-Melanocyte stimulating hormone, >=97% (HPLC) 200 WHNFPRLDDSXQCL-UAZQEYIDSA-N 1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(1 SIGMA-ALDRICH powder ≥97% (HPLC)
£511.18 (exc VAT) per 5MG
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