alpha-Lactalbumin from bovine milk, Type III, calcium depleted, >=85% (PAGE), lyophilized powder

alpha-Lactalbumin from bovine milk, Type III, calcium depleted, >=85% (PAGE), lyophilized powder

Application

?-Lactalbumin from bovine milk has been used:in indirect enzyme-linked immunosorbent assay (ELISA) and competitive ELISA methodsin binding of Hsp90 and HSJ1b analysisto inhibit the lysozyme CAP-RAST assay

Biochem/physiol Actions

Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Site-directed mutagenesis of Asp87 or Asp88 to Ala completely abolishes the strong calcium binding affinity and reduces the stimulation of lactose synthase to ﹤3.5% of the maximal rate.

?-Lactalbumin is the cheif protein in human milk. It consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. ?-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native ?-lactalbumin from the reduced, denatured form. ?-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex.The mature protein consists of 123 amino acid residues (14 kD), and it has a three-dimensional structure with 1.7 Angstrom resolution, demonstrating four ?-helices and a triple stranded antiparallel ?-sheet.

General description

?-Lactalbumin is a small, globular, whey protein that has been found in all milk studied to date. It is a metalloprotein of approximately 14 kDa produced in the mammary glands.

Packaging

100, 500 mg in poly bottle

1 g in poly bottle

Quality

May contain traces of (NH4)2SO4 and sodium phosphate.

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Code Description Quality Level Manufacturer Form Assay Price Quantity
3591658 alpha-Lactalbumin from bovine milk, Type III, calcium depleted, >=85% (PAGE), lyophilized powder 200 SIGMA-ALDRICH lyophilized powder ≥85% (PAGE)
£254.89 (exc VAT) per 100MG
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3591659 alpha-Lactalbumin from bovine milk, Type III, calcium depleted, >=85% (PAGE), lyophilized powder 200 SIGMA-ALDRICH lyophilized powder ≥85% (PAGE)
£1,002.86 (exc VAT) per 1G
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3591660 alpha-Lactalbumin from bovine milk, Type III, calcium depleted, >=85% (PAGE), lyophilized powder 200 SIGMA-ALDRICH lyophilized powder ≥85% (PAGE)
£585.00 (exc VAT) per 500MG
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