alpha-DHED

alpha-DHED

Biochem/physiol Actions

α-DHED is a bioprecursor prodrug of 17α-estradiol ((Alfatradiol)) that results in 17α-estradiol being produced selectively in the brain with little production in the periphery. α-DHED has no estrogenic activity itself with little affinity for either ERα and ERβ estrogen receptors. 17α-estradiol (αE2) has been proposed to have potential roles in various neurodegenerative disorders including neuroprotection of the brain and the prevention/treatment of Alzheimer’;s disease, but peripheral side-effects on estrogen-sensitive organs have been problematic. α-DHED, a prodrug without estrogenic activity, could help alleviate those concerns.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576257 alpha-DHED white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£434.57 (exc VAT) per EACH
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3576258 alpha-DHED white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£107.95 (exc VAT) per EACH
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