AFTIN-4

AFTIN-4

Biochem/physiol Actions

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575115 AFTIN-4 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
£580.82 (exc VAT) per 25MG
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3575116 AFTIN-4 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
£253.50 (exc VAT) per 5MG
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