ABC99

ABC99

Biochem/physiol Actions

ABC99 is an N-hydroxyhydantoin (NHH) carbamate-based irreversible, potent and selective inhibitor against the serine hydrolase activity of the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM against NOTUM-mediated labeling of fluorophosphonate (FP) probe), an enzyme that reverses the posttranslational O-linked palmitoleate modification of Wnt proteins. ABC99 prevents NOTUM-mediated negative regulation against Wnt3A-dependent cellular signaling (EC50 = 89 nM by HEK293T TOPflash reporter assay) with excellent selectivity over 65 other serine hydrolases, including PPT1.

Inhibition of NOTUM has therapeutic use in treating degenerative diseases including osteopenia and osteoporosis.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576277 ABC99 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£469.39 (exc VAT) per 25MG
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3576278 ABC99 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£115.61 (exc VAT) per 5MG
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