A939572

A939572

Biochem/physiol Actions

A939572 is an orally available piperidine-aryl urea-based small molecule that inhibits stearoyl-CoA desaturase 1 (SCD1) with high potency (IC50 = 37 nM/hSCD1 and ﹤4 nM/mSCD1) with little hERG channel blockade activity (IC50 >100 µM). When administered in ob/ob mice, A939572 effectively reduces desaturation indices in vivo (18:0/18:1n9 ratio from 26.9 to 8.47 in liver; from 15.4 to 7.35 in plasma post 5-day 10 mg/kg bid p.o.). A939572 is a useful tool for probing SCD1-mediated physiological and pathological processes both in cultures (50 nM-10 µM) and in vivo (5-10 mg/kg i.p. or 10 mg/kg p.o. in mice).

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576196 A939572 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£408.11 (exc VAT) per 25MG
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3576197 A939572 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£94.44 (exc VAT) per 5MG
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