51164

51164

Biochem/physiol Actions

51164 is a neuron penetrant, potent and selective positive allosteric modulator of TRPC6 channels that activates neuronal store-operated calcium entry (nSOCE) in the hippocampal neurons spines. 51164 fully rescues mushroom spines in Aß42-treated neurons. It restores long-term potentiation (LTP) deficit in 6 months old hippocampal slices from 5xFAD mouse model.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576569 51164 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£385.82 (exc VAT) per EACH
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3576570 51164 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£95.41 (exc VAT) per EACH
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