4-Methylumbelliferone sodium salt, >=98% (HPLC), crystalline

4-Methylumbelliferone sodium salt, >=98% (HPLC), crystalline

Application

4-Methylumbelliferone sodium salt has been used:as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liveras a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate actionin cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer

Biochem/physiol Actions

4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5?-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.

General description

4-methylumbelliferone (4-MU) is a coumarin derivative.

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3578413 4-Methylumbelliferone sodium salt, >=98% (HPLC), crystalline yellow 200 JGMQHDNPUCPRQE-UHFFFAOYSA-M 1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
£579.43 (exc VAT) per 100G
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3578414 4-Methylumbelliferone sodium salt, >=98% (HPLC), crystalline yellow 200 JGMQHDNPUCPRQE-UHFFFAOYSA-M 1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
£95.83 (exc VAT) per 10G
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3578415 4-Methylumbelliferone sodium salt, >=98% (HPLC), crystalline yellow 200 JGMQHDNPUCPRQE-UHFFFAOYSA-M 1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
£211.71 (exc VAT) per 25G
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