4-Chloro-L-phenylalanine,

4-Chloro-L-phenylalanine,

Application

4-Chloro-L-phenylalanine (L-PCPA) has been used: to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH) to study its behavioral and electrographic effects on epileptic senegalese baboon (Papio papio) as a substrate for Chromobacterium violaceum phenylalanine hydroxylaseto incubate sea urchin embryos for immunohistochemistry

Biochem/physiol Actions

4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation.

Tryptophan hydroxylase inhibitor.

Packaging

1 g in glass bottle

250 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

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Code Description Quality Level mp InChI key InChI Manufacturer Storage Temp. Form Price Quantity
3591020 4-Chloro-L-phenylalanine, 200 263 °C (dec.) (lit.) NIGWMJHCCYYCSF-QMMMGPOBSA-N 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1 SIGMA-ALDRICH −20°C powder
£649.07 (exc VAT) per 1G
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3591021 4-Chloro-L-phenylalanine, 200 263 °C (dec.) (lit.) NIGWMJHCCYYCSF-QMMMGPOBSA-N 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1 SIGMA-ALDRICH −20°C powder
£192.21 (exc VAT) per 250MG
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