3-Isobutyl-1-methylxanthine, >=99% (HPLC), powder

Descriptions

Application

3-Isobutyl-1-methylxanthine has been used:in the differentiation of mesenchymal stem cells (MSC)as a culture medium supplement for inducing adipogenic differentiationas a supplement in Krebs-Ringer buffer with HEPES (KRBH) solution for inducing glucose-stimulated insulin secretion (GSIS)in the characterization of adipose-derived mesenchymal stem cellsin cyclic adenosine monophosphate (cAMP) assayin phosphodiesterase (PDE) inhibition

Biochem/physiol Actions

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC₅₀: 1.3 µM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

General description

3-isobutyl-1-methylxanthine/IBMX is a non-selective, non-specific inhibitor of cAMP and cGMP phosphodiesterases. IBMX can induce melanogenesis, and can be used as a positive control in melanogenesis research. In oocyte research, IBMX assists in maintaining the germinal vesicle (GV) arrest of prophase I oocytes.

Packaging

100 mg in poly bottle

1, 5 g in poly bottle

250 mg in poly tube

Specifications

No detailed specifications are available for this product.

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Code	Description	Colour	Quality Level	mp	InChI key	InChI	Manufacturer	Storage Temp.	Solubility	Form	Assay	Price	Quantity
3577812	3-Isobutyl-1-methylxanthine, >=99% (HPLC), powder	white to off-white	200	200-201 °C (lit.)	APIXJSLKIYYUKG-UHFFFAOYSA-N	1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)	SIGMA-ALDRICH	−20°C	ethanol: 10 mg/mL; DMSO: 1 M (with gentle warming)	powder	≥99% (HPLC)	£55.58 (exc VAT) per 100MG	- +
3577813	3-Isobutyl-1-methylxanthine, >=99% (HPLC), powder	white to off-white	200	200-201 °C (lit.)	APIXJSLKIYYUKG-UHFFFAOYSA-N	1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)	SIGMA-ALDRICH	−20°C	ethanol: 10 mg/mL; DMSO: 1 M (with gentle warming)	powder	≥99% (HPLC)	£279.96 (exc VAT) per 1G	- +
3577814	3-Isobutyl-1-methylxanthine, >=99% (HPLC), powder	white to off-white	200	200-201 °C (lit.)	APIXJSLKIYYUKG-UHFFFAOYSA-N	1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)	SIGMA-ALDRICH	−20°C	ethanol: 10 mg/mL; DMSO: 1 M (with gentle warming)	powder	≥99% (HPLC)	£100.98 (exc VAT) per 250MG	- +
3577815	3-Isobutyl-1-methylxanthine, >=99% (HPLC), powder	white to off-white	200	200-201 °C (lit.)	APIXJSLKIYYUKG-UHFFFAOYSA-N	1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)	SIGMA-ALDRICH	−20°C	ethanol: 10 mg/mL; DMSO: 1 M (with gentle warming)	powder	≥99% (HPLC)	£1,100.36 (exc VAT) per 5G	- +