3-Iodo-L-tyrosine,

3-Iodo-L-tyrosine,

Application

3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.

Biochem/physiol Actions

TH (tyrosine 3-hydroxylase) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. Mutations in TH are associated with tyrosine hydroxylase deficiency, leading to conditions such as infantile parkinsonism and DOPA (dopamine)-responsive dystonia as well as encephalopathy with perinatal onset.

3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.

Tyrosine hydroxylase inhibitor.

General description

Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3?-tri-iodothyronine (T3) or 3,3?,5?-tri-iodothyronine (rT3).

Packaging

1, 5, 25 g in poly bottle

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Code Description Quality Level mp InChI key InChI Manufacturer Impurities Solubility Price Quantity
3591558 3-Iodo-L-tyrosine, 200 210 °C (dec.) (lit.) UQTZMGFTRHFAAM-ZETCQYMHSA-N 1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
£106.14 (exc VAT) per 1G
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3591559 3-Iodo-L-tyrosine, 200 210 °C (dec.) (lit.) UQTZMGFTRHFAAM-ZETCQYMHSA-N 1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
£1,090.61 (exc VAT) per 25G
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3591560 3-Iodo-L-tyrosine, 200 210 °C (dec.) (lit.) UQTZMGFTRHFAAM-ZETCQYMHSA-N 1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
£410.89 (exc VAT) per 5G
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