3-Aminopropionitrile fumarate salt, metabolite

3-Aminopropionitrile fumarate salt, metabolite

Application

3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:to inhibit collagen cross-linking during microtissue formation and culturein LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assayin lysyl oxidase (LOX) activity assayto study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids

Biochem/physiol Actions

3-Aminopropionitrile (?-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.

In mammals, metabolism of 3-aminopropionitrile leads to release of cyanide ions. Metabolic activity is localized in the microsomal fraction of the liver, and is believed to proceed through a free-radical pathway.

Packaging

5, 10, 25 g in poly bottle

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Code Description Quality Level mp InChI key InChI Manufacturer Form Assay Price Quantity
3577604 3-Aminopropionitrile fumarate salt, metabolite 200 177 °C (dec.) (lit.) NYMXYZMHOZAPHQ-SEPHDYHBSA-N 1S/C4H4O4.2C3H6N2/c5-3(6)1-2-4(7)8;2*4-2-1-3-5/h1-2H,(H,5,6)(H,7,8);2*1-2,4H2/b2-1+;; SIGMA-ALDRICH powder ≥98% (TLC)
£221.46 (exc VAT) per 10G
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3577605 3-Aminopropionitrile fumarate salt, metabolite 200 177 °C (dec.) (lit.) NYMXYZMHOZAPHQ-SEPHDYHBSA-N 1S/C4H4O4.2C3H6N2/c5-3(6)1-2-4(7)8;2*4-2-1-3-5/h1-2H,(H,5,6)(H,7,8);2*1-2,4H2/b2-1+;; SIGMA-ALDRICH powder ≥98% (TLC)
£456.86 (exc VAT) per 25G
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3577606 3-Aminopropionitrile fumarate salt, metabolite 200 177 °C (dec.) (lit.) NYMXYZMHOZAPHQ-SEPHDYHBSA-N 1S/C4H4O4.2C3H6N2/c5-3(6)1-2-4(7)8;2*4-2-1-3-5/h1-2H,(H,5,6)(H,7,8);2*1-2,4H2/b2-1+;; SIGMA-ALDRICH powder ≥98% (TLC)
£118.25 (exc VAT) per 5G
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