1(S),9-(-)-Bicuculline methiodide, >=95.0% (HPCE)

1(S),9-(-)-Bicuculline methiodide, >=95.0% (HPCE)

Application

1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs).

Biochem/physiol Actions

(-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor.

Features and Benefits

This compound is featured on the GABAA Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesteraseinhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP).

Preparation Note

prepared from (+)-bicuculline

No detailed specifications are available for this product.

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Code Description Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3573212 1(S),9-(-)-Bicuculline methiodide, >=95.0% (HPCE) 100 HKJKCPKPSSVUHY-GRTNUQQKSA-M 1S/C21H20NO6.HI/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18 SIGMA-ALDRICH H2O: 10 mg/mL, almost clear, greenish-yellow powder ≥95.0% (HPCE)
£62.82 (exc VAT) per 10MG
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+
3573213 1(S),9-(-)-Bicuculline methiodide, >=95.0% (HPCE) 100 HKJKCPKPSSVUHY-GRTNUQQKSA-M 1S/C21H20NO6.HI/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18 SIGMA-ALDRICH H2O: 10 mg/mL, almost clear, greenish-yellow powder ≥95.0% (HPCE)
£220.07 (exc VAT) per 50MG
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+