[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt, >=97% (HPLC)

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt, >=97% (HPLC)

Amino Acid Sequence

Tyr-Ala-Gly-Nme-Phe-Gly-ol

Application

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO has been used:for use as a positive control in the assay of G-protein activation with ?-opioid receptor, to assay the inhibition of cAMP inhibition by DAMGO for the determination of the suppression of contraction by opioid receptors to determine whether the peripheral application of DAMGO suppresses the hypertonic saline (HS)-induced masseter nociception in slightly anaesthetized rats

Biochem/physiol Actions

Enkephalin analog that is a selective agonist at µ-opioid receptors.

General description

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO is a full agonist of the ?-opioid receptor. ?-opioid receptor is encoded by the OPRM1 gene, which has a predominant expression in reward-processing areas of brain. It acts as a receptor for endogenous opioids such as ?-endorphin, encephalin, as well as foreign opioids such as morphine, heroin, and methadone.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Code Description Quality Level InChI key InChI Manufacturer Storage Temp. Assay Price Quantity
3591142 [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt, >=97% (HPLC) 100 XZZYKCKUDLGXJA-NJUGUJQKSA-N 1S/C26H35N5O6.C2H4O2/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18;1-2(3)4/h3-11,17,21-22,32-33H SIGMA-ALDRICH −20°C ≥97% (HPLC)
£552.96 (exc VAT) per 10MG
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3591143 [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt, >=97% (HPLC) 100 XZZYKCKUDLGXJA-NJUGUJQKSA-N 1S/C26H35N5O6.C2H4O2/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18;1-2(3)4/h3-11,17,21-22,32-33H SIGMA-ALDRICH −20°C ≥97% (HPLC)
£96.66 (exc VAT) per 1MG
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3591144 [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt, >=97% (HPLC) 100 XZZYKCKUDLGXJA-NJUGUJQKSA-N 1S/C26H35N5O6.C2H4O2/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18;1-2(3)4/h3-11,17,21-22,32-33H SIGMA-ALDRICH −20°C ≥97% (HPLC)
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3591145 [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt, >=97% (HPLC) 100 XZZYKCKUDLGXJA-NJUGUJQKSA-N 1S/C26H35N5O6.C2H4O2/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18;1-2(3)4/h3-11,17,21-22,32-33H SIGMA-ALDRICH −20°C ≥97% (HPLC)
£288.32 (exc VAT) per 5MG
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