(+/-)-Baclofen, >=98% (TLC), solid

(+/-)-Baclofen, >=98% (TLC), solid

Application

(±)-Baclofen has been used as ?-aminobutyric acid receptor B GABABreceptor agonist: as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicityto test its effects on in vivo motor function tests and performance of mutant miceto test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA) to test its effect in reducing dendritic excitability in Purkinje neurons

Biochem/physiol Actions

GABAB receptor agonist; skeletal muscle relaxant; antispastic agent.

Baclofen, a ?-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a ?-aminobutyric acid receptor B (GABAB) agonist, baclofen may be involved in the potentiation of dendritic potassium K+channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR)in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3589724 (+/-)-Baclofen, >=98% (TLC), solid white to very faintly yellow 100 KPYSYYIEGFHWSV-UHFFFAOYSA-N 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
£867.75 (exc VAT) per 10G
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+
3589725 (+/-)-Baclofen, >=98% (TLC), solid white to very faintly yellow 100 KPYSYYIEGFHWSV-UHFFFAOYSA-N 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
£103.91 (exc VAT) per 500MG
-
+
3589726 (+/-)-Baclofen, >=98% (TLC), solid white to very faintly yellow 100 KPYSYYIEGFHWSV-UHFFFAOYSA-N 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
£559.93 (exc VAT) per 5G
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+