(+/-)-Bay K8644, calcium channel agonist

(+/-)-Bay K8644, calcium channel agonist

Application

(±)-Bay K8644 has been used as an agonist for voltage sensitive calcium channels (VSCCs) in interneurons, L-type calcium channel (LTCC) in human embryonic kidney 293 cells and viscerofugal neurons.

Biochem/physiol Actions

(±)-Bay K8644 is a 1,4-dihydropyridine (DHP) derivative and an agonist for L-type Ca2+ channels. However, it?s enantiomers (-)-BAY k8644 and (+)-BAY k8644 have opposing functionality with respect to Ca2+ channels as high-potency agonist and low-potency antagonist, respectively. (±)-Bay K8644 increases influx of Ca2+ specifically at voltage-gated calcium channels. It constricts blood vessels and heart contraction.

Increases influx of Ca2+ specifically at voltage-gated calcium channels.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level mp InChI key InChI Manufacturer Form Assay Price Quantity
3577637 (+/-)-Bay K8644, calcium channel agonist yellow to dark yellow 100 168-170 °C ZFLWDHHVRRZMEI-UHFFFAOYSA-N 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3 SIGMA-ALDRICH powder ≥97.5% (HPLC)
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3577638 (+/-)-Bay K8644, calcium channel agonist yellow to dark yellow 100 168-170 °C ZFLWDHHVRRZMEI-UHFFFAOYSA-N 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3 SIGMA-ALDRICH powder ≥97.5% (HPLC)
£387.21 (exc VAT) per 5MG
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