(Z)-ENDOXIFEN

(Z)-ENDOXIFEN

Application

(Z)-Endoxifen has been used to demonstrate the lack of contribution of subventricular zone and leptomeningeal cells in a study determining the generation of neuroblasts from astrocytes.

Biochem/physiol Actions

(Z)-Endoxifen (endoxifen) is an active tamoxifen metabolite generated via actions of cytochrome P450 (CYP) enzymes CYP3A4/5 and CYP2D6. Endoxifen is more potent than tamoxifen as a selective estrogen receptor modulator (SERM) both in vitro and in vivo with good pharmacokinetics and oral availability (~80% MCF-7 tumor growth inhibition with 4-8 mg/kg/day endoxifen or 20 mg/kg/day tamoxifen in mice via p.o.). Endoxifen also exhibits 4-fold higher PKC inhibitory potency than tamoxifen and can overcome tamoxifen resistance due to cytochrome CYP2D6 polymorphism.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576212 (Z)-ENDOXIFEN white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£871.93 (exc VAT) per 25MG
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3576213 (Z)-ENDOXIFEN white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£245.14 (exc VAT) per 5MG
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