(+)-Bicuculline, >=97.0% (TLC)

(+)-Bicuculline, >=97.0% (TLC)

Application

Bicuculline has been used: as a compound to compare pharmacodynamics and network activity profiles of conolidine/cannabidiolto study the effects of chronic caffeine administration on the function of GABAA receptorto isolate N-methyl-D-aspartate receptor (NMDAR)-specific evoked and miniature excitatory postsynaptic currents (eEPSCs and mEPSCs) in neurons of rats

Biochem/physiol Actions

(+)-Bicuculline is a GABAA receptor antagonist.

(+)-Bicuculline acts as a competitive inhibitor of GABA liganding binding to the receptor.

Features and Benefits

This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.

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Code Description Quality Level mp InChI key InChI Manufacturer Form Assay Price Quantity
3573209 (+)-Bicuculline, >=97.0% (TLC) 100 193-197 °C IYGYMKDQCDOMRE-ZWKOTPCHSA-N 1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1 SIGMA-ALDRICH powder ≥97.0% (TLC)
£185.25 (exc VAT) per 100MG
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3573210 (+)-Bicuculline, >=97.0% (TLC) 100 193-197 °C IYGYMKDQCDOMRE-ZWKOTPCHSA-N 1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1 SIGMA-ALDRICH powder ≥97.0% (TLC)
£62.82 (exc VAT) per 25MG
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+
3573211 (+)-Bicuculline, >=97.0% (TLC) 100 193-197 °C IYGYMKDQCDOMRE-ZWKOTPCHSA-N 1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1 SIGMA-ALDRICH powder ≥97.0% (TLC)
£539.04 (exc VAT) per 500MG
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