CD61 (GPIIIA) (EP65)

Descriptions

General description

CD61, also known as GPIIIa and Integrin beta-3, is a glycoprotein encoded by the ITGB3 gene. CD61 heterodimerize with other cluster of differentiation molecules resulting in transmembrane integrins, facilitating cell to cell interactions and signal transduction. CD61 combines with CD41 to form platelet glycoprotein IIb/IIIa that serves as a receptor for fibrinogen and fibronectin. Platelet activation causes a conformational change in the glycoprotein to bind soluble fibrinogen to from a platelet plug. Alternative, CD61 can heterodimerize with CD51 to form Integrin alpha V beta 3, a receptor for vitronectin and von Willebrand factor. CD61 is expressed in the membrane and cytoplasm of platelets and megakaryocytes across diverse tissue types. Endothelium is also stained. Most cases of acute megakaryoblastic leukemia (AML M7) are positive for CD61.

Other Notes

For a copy of the IFU and CofA contact IVDorder@ABCAM.comFor Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Quality

IVD

RUO

Specifications

No detailed specifications are available for this product.

Downloads

There are no downloads for this product.

Code	Description	Quality Level	Manufacturer	Technique(s)	Storage Temp.	Form	Price	Quantity
3573085	CD61 (GPIIIA) (EP65) 1 ML	500	SIGMA-ALDRICH	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200	2-8°C	buffered aqueous solution	Click Add to Quote for price and delivery	- +
3573086	CD61 (GPIIIA) (EP65) 0.1 ML	500	SIGMA-ALDRICH	-	2-8°C	buffered aqueous solution	£427.44 (exc VAT) per EACH	- +
3573087	CD61 (GPIIIA) (EP65) 0.1 ML RUO	-	SIGMA-ALDRICH	-	-	-	£427.44 (exc VAT) per EACH	- +
3573088	CD61 (GPIIIA) (EP65) 1 ML RUO	-	SIGMA-ALDRICH	-	-	-	Click Add to Quote for price and delivery	- +