OLIG2 (EP112)

Descriptions

General description

Olig2, a basic helix–loop–helix transcription factor, is involved in oligodendroglial specification. Olig2 expression has been reported in most glial tumors, such as oligodendrogliomas and astrocytomas.^1-2 More than half of glioblastomas are weakly positive for Olig2. No Olig2 expression has been found in the non-glial tumors including neuroepithelial tumors, ependymomas, subependymomas, medulloblastomas, and nonneuroepithelial tumors, such as CNS lymphomas, meningiomas, schwannomas, atypical teratoid/rhabdoid tumor, and haemangioblastomas.^1-2 In order to characterize cellular subtypes that constitute astrocytomas, oligoastrocytomas and oligodendrogliomas, double labeling of Olig2 and GFAP has been performed which identified two phenotypically distinct tumor populations. The first is Olig2+/GFAP– which has an oligodendroglial morphology, corresponding to pure oligodendrogliomas that contain only oligodendroglial cells; the second is Olig2–/GFAP+ which has an astrocytic phenotype, including not only oligoastrocytomas, but also WHO astrocytomas.^1-2

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

Olig2 Positive Control Slides, Product No. 387S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality

IVD

RUO

Specifications

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Code	Description	Manufacturer	Further Info	Form	Price	Quantity
3573040	OLIG2 (EP112); 0.1ml; Concentrate	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	buffered aqueous solution	£290.93 (exc VAT) per EACH	- +
3573041	OLIG2 (EP112); 0.5ml; Concentrate	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	buffered aqueous solution	£763.87 (exc VAT) per EACH	- +
3573042	OLIG2 (EP112); 1ml; Concentrate	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	buffered aqueous solution	Click Add to Quote for price and delivery	- +
3573043	OLIG2 (EP112); 1ml; Predilute	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	buffered aqueous solution	£242.16 (exc VAT) per EACH	- +
3573044	OLIG2 (EP112); 7ml; Predilute	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	buffered aqueous solution	£789.88 (exc VAT) per EACH	- +