MONOCLONAL TSH (EP254)

Descriptions

General description

Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a peptide hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulate the endocrine function of the thyroid gland. TSH is a glycoprotein and consists of two subunits, the alpha and the beta subunit, which are non-covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones: Follicle stimulating hormone and luteinizing hormone and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity. Anti-TSH reacts with TSH-producing cells (thyrotrophs), and is a useful marker in classification of pituitary tumors and the differential identification of primary and metastatic tumors in the pituitary gland.^1-5

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

TSH Positive Control Slides, Product No. 211S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality

IVD

RUO

Specifications

No detailed specifications are available for this product.

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Code	Description	Quality Level	Manufacturer	Further Info	Storage Temp.	Form	Price	Quantity
3572863	MONOCLONAL TSH (EP254)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£240.55 (exc VAT) per EACH	- +
3572864	MONOCLONAL TSH (EP254)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£677.74 (exc VAT) per EACH	- +
3572865	MONOCLONAL TSH (EP254)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£1,090.55 (exc VAT) per EACH	- +
3572866	MONOCLONAL TSH (EP254)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£198.29 (exc VAT) per EACH	- +
3572867	MONOCLONAL TSH (EP254)	100; 500	SIGMA-ALDRICH	(For In Vitro Diagnostic Use in Select Regions (See Chart))	2-8°C	buffered aqueous solution	£484.32 (exc VAT) per EACH	- +