MONOCLONAL MESOTHELIN (EP140)

MONOCLONAL MESOTHELIN (EP140)

General description

Mesothelin is a 40 kDa glycosyl-phosphatudylinositol-anchored glycoprotein cleaved from a 71kDa precursor protein encoded by the human mesothelin gene. Mesothelin is present on the surface of normal mesothelial cells.1 Although the function of mesothelin is unknown, it is overexpressed in a wide variety of cancers including mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.1-6 Mesothelin has proven to be a valuable marker for pancreatic ductal adenocarcinoma due to its strong reactivity in tumor tissue and absence in normal pancreas.1, 3-4 Metastatic renal cell carcinoma can present clinical patterns that mimic primary mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.2, 4-6 Mesothelin has demonstrated utility in the differential diagnosis between these primary tumors and corresponding metastatic renal cell carcinoma within the context of an antibody panel.4-6?

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

Mesothelin Positive Control Slides, Product No. 439S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality

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Code Description Quality Level Manufacturer Further Info Storage Temp. Form Price Quantity
3573061 MONOCLONAL MESOTHELIN (EP140) 100; 500 SIGMA-ALDRICH (For In Vitro Diagnostic Use in Select Regions (See Chart)) 2-8°C buffered aqueous solution
£589.97 (exc VAT) per EACH
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