MONOCLONAL PAX-2 (EP235)

MONOCLONAL PAX-2 (EP235)

General description

PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported ﹤em>in vitro﹤/em> with transformation of cell cultures and?﹤em>in vivo﹤/em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.1 Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.2 More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from?breast carcinoma (anti-PAX-2 negative).3

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality

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Code Description Quality Level Manufacturer Further Info Storage Temp. Form Price Quantity
3572970 MONOCLONAL PAX-2 (EP235) 100; 500 SIGMA-ALDRICH (For In Vitro Diagnostic Use in Select Regions (See Chart)) 2-8°C buffered aqueous solution
£276.30 (exc VAT) per EACH
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