Cholesterol, powder, BioReagent, suitable for cell culture, >=99.0%

Cholesterol, powder, BioReagent, suitable for cell culture, >=99.0%

Stock Code: 3571433
Manufacturer Part No: C3045-5G
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£88.75 (exc VAT) per 5G
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Application


Cholesterol has been used:as a medium supplement in chorionic villous tissue culture form placentaas a component of hormone pellet for implantation in mice ovaryfor inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1


Biochem/physiol Actions


Major component of all biological membranes; ~25% of total brain lipid is cholesterol.


General description


Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression.


Packaging


5, 25, 100 g in poly bottle

Pack5G
InChI keyHVYWMOMLDIMFJA-DPAQBDIFSA-N
InChI1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25
bp360 °C (lit.)
ManufacturerSIGMA-ALDRICH
Density1.067 g/mL at 25 °C (lit.)
Formpowder
Assay≥99%

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