Angiotensin Converting Enzyme from porcine kidney, lyophilized powder, >=10 units/mg protein (Bradfo

Angiotensin Converting Enzyme from porcine kidney, lyophilized powder, >=10 units/mg protein (Bradfo

Application

Angiotensin converting enzyme from porcine kidney has been used in in vitro angiotensin-converting enzyme (ACE) inhibition assay.

Biochem/physiol Actions

Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II, which regulates the fluid-electrolyte balance and systemic blood pressure. ACE inhibits the vasodilator, bradykinin. ACE inhibitors are used to treat high blood pressure.

Removes C-terminal dipeptides from susceptible substrates, e.g., angiotensin I and bradykinin.

General description

ACE is a monomer with molecular weight of ~170 kDapH range for activity: 7-8.5 Temperature optimum: 37 °CZinc is required for activityInhibitors: captopril, enalaprilat, lisinopril etc. (1-10 µM)

Angiotensin converting enzyme (ACE) is encoded by the gene, mRNA-decapping enzyme subunit 1 (DCP1). It is a zinc metalloprotease, which belongs to the M2 family.

Physical form

Lyophilized powder containing Tris buffer salts.

Unit Definition

One unit will produce 1.0 ·µmole of hippuric acid from Hippuryl-His-Leu per min in 50 mM HEPES and 300 mM NaCl at pH 8.3 at 37 °C.

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Code Description Quality Level Manufacturer Storage Temp. Form Price Quantity
3589481 Angiotensin Converting Enzyme from porcine kidney, lyophilized powder, >=10 units/mg protein (Bradfo 200 SIGMA-ALDRICH −20°C lyophilized powder
£259.07 (exc VAT) per EACH
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3589482 Angiotensin Converting Enzyme from porcine kidney, lyophilized powder, >=10 units/mg protein (Bradfo 200 SIGMA-ALDRICH −20°C lyophilized powder
£834.32 (exc VAT) per EACH
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3589483 Angiotensin Converting Enzyme from porcine kidney, lyophilized powder, >=10 units/mg protein (Bradfo 200 SIGMA-ALDRICH −20°C lyophilized powder
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